Pub. Date : 1995 Dec
PMID : 8689952
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, we provided evidence indicating that cimetidine selectively inhibits CYP2C11 in the rat and that it acts by forming a metabolite-intermediate (MI) complex. | Cimetidine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | These results are consistent with the hypothesis that cimetidine inhibits CYP in vivo in the rat by forming an MI complex, largely with CYP2C11, and that this complex can be generated in vitro by incubating microsomes with cimetidine in the presence of NADPH. | Cimetidine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |