Title : Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation.

Pub. Date : 1996 Jun

PMID : 8681486






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LKM-2 antibodies (anti-CYP2C) caused a 75% to 100% inhibition of norantipyrine and a 58% to 80% inhibition of 3-hydroxymethylantipyrine formation. Edaravone cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 LKM-2 antibodies (anti-CYP2C) caused a 75% to 100% inhibition of norantipyrine and a 58% to 80% inhibition of 3-hydroxymethylantipyrine formation. 3-hydroxymethylantipyrine cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 The CYP2C subfamily contains the predominant enzymes for norantipyrine formation, and CYP1A2 is also involved. Edaravone cytochrome P450 family 2 subfamily C member 9 Homo sapiens
4 Formation of 3-hydroxymethylantipyrine is mediated by CYP1A2 and CYP2C9. 3-hydroxymethylantipyrine cytochrome P450 family 2 subfamily C member 9 Homo sapiens