Title : The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions.

Pub. Date : 1996 Jun

PMID : 8681455






1 Functional Relationships(s)
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1 In particular, the CYP102-derived structures of CYP3A4, CYP2D6 and CYP2C9 are able to rationalize the routes of tamoxifen metabolism reported in human subjects. Tamoxifen cytochrome P450 family 2 subfamily C member 9 Homo sapiens