Title : Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes.

Pub. Date : 1996 Jul 12

PMID : 8678911






2 Functional Relationships(s)
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1 Our data suggest that CYP2C11, a CYP3A isozyme and an unidentified P450 species are involved in complex formation with orphenadrine, but exclude the involvement of CYP1A1/2 and CYP2B1/2. Orphenadrine cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 The capability of CYP2C11 to form a metabolite complex with orphenadrine is strongly suggested for the following reasons: 1. Orphenadrine cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus