Title : Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.

Pub. Date : 1996 Apr

PMID : 8657102






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Substitution of either serine blocks or slows down induction of IkappaBalpha degradation. Serine NFKB inhibitor alpha Homo sapiens
2 As substitution of a conserved lysine residue slows down the ubiquitination and degradation of IkappaBalpha without affecting its phosphorylation, polyubiquitination is required for inducible IkappaB degradation. Lysine NFKB inhibitor alpha Homo sapiens