Title : Type 1 phosphatase inhibitors reduce the restoration of guanine nucleotide exchange activity of eukaryotic initiation factor 2B inhibited reticulocyte lysates rescued by hemin.

Pub. Date : 1996 Mar 15

PMID : 8619603






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phosphorylation of eIF-2alpha impairs the guanine nucleotide exchange activity of eIF-2B and thereby inhibits or shuts off protein synthesis. Guanine Nucleotides eukaryotic translation initiation factor 2A Homo sapiens
2 Delayed addition of hemin to shut-off lysates inhibits the eIF-2alpha kinase activity of HRI and restores protein synthesis; under those conditions, the endogenous phosphatase of the lysate dephosphorylates phosphorylated eIF-2alpha and restores eIF-2B activity. Hemin eukaryotic translation initiation factor 2A Homo sapiens
3 Delayed addition of hemin to shut-off lysates inhibits the eIF-2alpha kinase activity of HRI and restores protein synthesis; under those conditions, the endogenous phosphatase of the lysate dephosphorylates phosphorylated eIF-2alpha and restores eIF-2B activity. Hemin eukaryotic translation initiation factor 2A Homo sapiens