Title : Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol.

Pub. Date : 1995 Nov 27

PMID : 8615851






2 Functional Relationships(s)
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1 In contrast, in rats pretreated with the combination of ethanol and isopentanol, administration of APAP caused a dramatic increase in serum levels of AST, along with marked central lobular necrosis, including steatosis and ischemic changes. isopentyl alcohol glutamic-oxaloacetic transaminase 2 Rattus norvegicus
2 We had reported previously that combined treatment of rats with ethanol and isopentanol resulted in additive to synergistic increases in CYP3A, with no further increases in CYP2E than that caused by ethanol alone. isopentyl alcohol cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus