Title : Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents.

Pub. Date : 1996 Jan

PMID : 8613793






2 Functional Relationships(s)
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1 By immunoblotting procedures using subunit-specific antibodies, we found that repeated, but not acute, cocaine treatment increased the levels of immunoreactivity of GluR1 (an AMPA receptor subunit) and NMDAR1 (an NMDA receptor subunit) in the ventral tegmental area (VTA), a nucleus containing mesolimbic DA neurons. Cocaine glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus
2 Although morphine delivered by subcutaneous pellet implantation had no significant effect on subunit levels, morphine delivered intermittently by subcutaneous injections of escalating doses elevated GluR1 levels in the VTA. Morphine glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus