Pub. Date : 1993 May 28
PMID : 8509219
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methylglyoxal strongly inactivated glyceraldehyde 3-phosphate dehydrogenase (GA3PD) of the malignant cells, whereas MG has little inactivating effect on this enzyme from several normal sources. | Pyruvaldehyde | glyceraldehyde-3-phosphate dehydrogenase | Mus musculus |
| 2 | Methylglyoxal strongly inactivated glyceraldehyde 3-phosphate dehydrogenase (GA3PD) of the malignant cells, whereas MG has little inactivating effect on this enzyme from several normal sources. | Pyruvaldehyde | glyceraldehyde-3-phosphate dehydrogenase | Mus musculus |
| 3 | Methylglyoxal has little inactivating effect on glucose 6-phosphate dehydrogenase (G6PD), and no effect on L-lactate dehydrogenase (LDH) of the malignant cells. | Pyruvaldehyde | glucose-6-phosphate dehydrogenase 2 | Mus musculus |
| 4 | Glucose-dependent L-lactic acid formation of EAC-cell-free homogenate was strongly inhibited by MG, but when GA3PD of normal cells was added to this homogenate, significant lactate formation was observed even in the presence of MG. Methylglyoxal also inhibited the respiration of EAC-cell mitochondria. | Pyruvaldehyde | glyceraldehyde-3-phosphate dehydrogenase | Mus musculus |
| 5 | Studies reported herein strongly suggest that the tumoricidal effect of MG is mediated at least in part through the inhibition of mitochondrial respiration and inactivation of GA3PD, and this enzyme may play an important role in the high glycolytic capacity of the malignant cells. | Pyruvaldehyde | glyceraldehyde-3-phosphate dehydrogenase | Mus musculus |