Protein Name glyceraldehyde-3-phosphate dehydrogenase
Organism Mus musculus
Gene ID 14433
Gene Symbol

Gapdh

UniProt P16858 (G3P_MOUSE), D2KHZ9 (D2KHZ9_MOUSE), A0A0A0MQF6 (A0A0A0MQF6_MOUSE)
Relationships Total Number of functionally related compound(s) : 157
Total Number of Articles : 149
Description

glyceraldehyde-3-phosphate dehydrogenase

Gene Summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]

synonyms
  • glyceraldehyde-3-phosphate dehydrogenase
  • peptidyl-cysteine S-nitrosylase GAPDH
  • Gapd
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Properties