Title : Characterization of specific cytochrome P450 enzymes responsible for the metabolism of diazepam in hepatic microsomes of adult male rats.

Pub. Date : 1993 Jan 7

PMID : 8424823






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Antisera of the "male-specific" P450 enzyme CYP2C11 partially inhibited both DZ N-demethylase and C3 hydroxylase activities (60%) which resulted in decreased formations of N-desmethyl-DZ (NDZ) and 3-hydroxy-DZ (3HDZ), respectively. Nordazepam cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 Antisera of the "male-specific" P450 enzyme CYP2C11 partially inhibited both DZ N-demethylase and C3 hydroxylase activities (60%) which resulted in decreased formations of N-desmethyl-DZ (NDZ) and 3-hydroxy-DZ (3HDZ), respectively. Temazepam cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
3 Antisera of the "male-specific" P450 enzyme CYP2C11 partially inhibited both DZ N-demethylase and C3 hydroxylase activities (60%) which resulted in decreased formations of N-desmethyl-DZ (NDZ) and 3-hydroxy-DZ (3HDZ), respectively. Temazepam cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus