Pub. Date : 1993 Jul 15
PMID : 8333835
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | There is a genetic polymorphism in humans in the metabolism of S-mephenytoin which has been suggested to be mediated by either CYP2C18 or CYP2C9. | Mephenytoin | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 2 | We have isolated genomic clones for CYP2C9 and CYP2C18 from the liver of an individual phenotyped in vitro as an extensive metabolizer of S-mephenytoin. | Mephenytoin | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 3 | The availability of the sequences of the upstream regions and intron-exon junctions of CYP2C9 and CYP2C18 will allow future analysis of these genes in humans which differ in their ability to metabolize S-mephenytoin and other drugs. | Sulfur | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |