Pub. Date : 1994 Jan 20
PMID : 8304968
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antibodies raised to CYP2C11 and 2B1/2 inhibited TMO N-demethylation in hepatic microsomes of untreated and phenobarbital-treated rats, respectively. | tmo | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | Antibodies raised to CYP2C11 and 2B1/2 inhibited TMO N-demethylation in hepatic microsomes of untreated and phenobarbital-treated rats, respectively. | Nitrogen | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 3 | Antibodies raised to CYP2C11 and 2B1/2 inhibited TMO N-demethylation in hepatic microsomes of untreated and phenobarbital-treated rats, respectively. | Phenobarbital | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 4 | These results indicated that the N-demethylation of TMO is catalysed mainly by CYP2C11 and 2B1 in rat hepatic microsomes, and that human CYP3A4 and an unspecified isoform of the 2C subfamilies contribute to TMO N-demethylation in human liver. | Nitrogen | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |