Pub. Date : 1994 Nov 15
PMID : 7998928
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | Mercaptopurine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 2 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | Mercaptopurine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 3 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | methylmercaptopurine ribonucleoside | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 4 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | me-mpr | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 5 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | purine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 6 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | methylthio-imp | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 7 | 6-Mercaptopurine (6-MP) and methylmercaptopurine ribonucleoside (Me-MPR) are purine anti-metabolites which are both metabolized to methylthio-IMP (Me-tIMP), a strong inhibitor of purine synthesis de novo. | purine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 8 | 6-MP is converted into tIMP, and thereafter it is methylated to Me-tIMP by thiopurine methyltransferase, an S-adenosylmethionine (S-Ado-Met)-dependent conversion. | Mercaptopurine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 9 | 6-MP is converted into tIMP, and thereafter it is methylated to Me-tIMP by thiopurine methyltransferase, an S-adenosylmethionine (S-Ado-Met)-dependent conversion. | Mercaptopurine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 10 | 6-MP is converted into tIMP, and thereafter it is methylated to Me-tIMP by thiopurine methyltransferase, an S-adenosylmethionine (S-Ado-Met)-dependent conversion. | S-Adenosylmethionine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 11 | 6-MP is converted into tIMP, and thereafter it is methylated to Me-tIMP by thiopurine methyltransferase, an S-adenosylmethionine (S-Ado-Met)-dependent conversion. | S-Adenosylmethionine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 12 | 6-MP is converted into tIMP, and thereafter it is methylated to Me-tIMP by thiopurine methyltransferase, an S-adenosylmethionine (S-Ado-Met)-dependent conversion. | S-Adenosylmethionine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 13 | The effects of both 6-MP and Me-MPR can be ascribed to a decreased conversion of methionine into S-Ado-Met, due to the ATP depletion induced by the inhibition of purine synthesis de novo by Me-tIMP. | Methionine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 14 | The effects of both 6-MP and Me-MPR can be ascribed to a decreased conversion of methionine into S-Ado-Met, due to the ATP depletion induced by the inhibition of purine synthesis de novo by Me-tIMP. | S-Adenosylmethionine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 15 | The effects of both 6-MP and Me-MPR can be ascribed to a decreased conversion of methionine into S-Ado-Met, due to the ATP depletion induced by the inhibition of purine synthesis de novo by Me-tIMP. | Adenosine Triphosphate | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 16 | The effects of both 6-MP and Me-MPR can be ascribed to a decreased conversion of methionine into S-Ado-Met, due to the ATP depletion induced by the inhibition of purine synthesis de novo by Me-tIMP. | purine | TIMP metallopeptidase inhibitor 1 | Homo sapiens |