Title : Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EBIFs).

Pub. Date : 1994 Nov 16

PMID : 7986207






1 Functional Relationships(s)
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1 In the rat, clotrimazole was the most effective inducer, increasing expression of CYP 3A isozymes over 450-fold, CYP 2B1/2 30-fold and CYP 1A1/2 12-fold and suppressing expression of CYP 2C11 nearly 70%. Clotrimazole cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus