Title : CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

Pub. Date : 1994 Dec 2

PMID : 7982907






4 Functional Relationships(s)
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1 We showed that CD28 signaling, distinct from other stimuli such as phorbol 12-myristate 13-acetate, IL-1, and tumor necrosis factor-alpha, caused a sustained down-regulation of the inhibitor I kappa B alpha in Jurkat T cells. Tetradecanoylphorbol Acetate NFKB inhibitor alpha Homo sapiens
2 In contrast, the phorbol 12-myristate 13-acetate/ionomycin-mediated down-regulation of I kappa B alpha was prevented by CsA but not by rapamycin. Tetradecanoylphorbol Acetate NFKB inhibitor alpha Homo sapiens
3 In contrast, the phorbol 12-myristate 13-acetate/ionomycin-mediated down-regulation of I kappa B alpha was prevented by CsA but not by rapamycin. Ionomycin NFKB inhibitor alpha Homo sapiens
4 In contrast, the phorbol 12-myristate 13-acetate/ionomycin-mediated down-regulation of I kappa B alpha was prevented by CsA but not by rapamycin. Cyclosporine NFKB inhibitor alpha Homo sapiens