Title : Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P450 2C6/2C11 and 3A1.

Pub. Date : 1994 Jul-Aug

PMID : 7956732






1 Functional Relationships(s)
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Protein Name
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1 Preincubation with cimetidine (selective for inhibition of CYP2C11), but not troleandomycin (selective for inhibition of CYP3A1/2), inhibited metabolite formation. Cimetidine cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus