Pub. Date : 1994 Mar
PMID : 7907604
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. | Cyclosporine | CD40 molecule | Homo sapiens |
| 2 | Optimal expression of CD40 ligand required activation of protein kinase C and a rise in intracellular calcium concentration. | Calcium | CD40 molecule | Homo sapiens |
| 3 | CD40 ligand expression was inhibited by pretreatment of T cells with cyclosporin A. | Cyclosporine | CD40 molecule | Homo sapiens |
| 4 | Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. | Cyclosporine | CD40 molecule | Homo sapiens |
| 5 | Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. | Cyclosporine | CD40 molecule | Homo sapiens |
| 6 | Cyclosporin A inhibited IL-4-driven CD40 ligand-dependent IgE isotype switching in PBMC but did not inhibit IgE synthesis induced by CD40 mAb plus IL-4. | Cyclosporine | CD40 molecule | Homo sapiens |
| 7 | These results suggest that patients receiving cyclosporin A may be deficient in CD40 ligand-dependent T cell help. | Cyclosporine | CD40 molecule | Homo sapiens |