PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7907604-0 1994 Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. Cyclosporine 0-13 CD40 molecule Homo sapiens 23-27 7907604-3 1994 Optimal expression of CD40 ligand required activation of protein kinase C and a rise in intracellular calcium concentration. Calcium 102-109 CD40 molecule Homo sapiens 22-26 7907604-4 1994 CD40 ligand expression was inhibited by pretreatment of T cells with cyclosporin A. Cyclosporine 69-82 CD40 molecule Homo sapiens 0-4 7907604-5 1994 Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. Cyclosporine 0-13 CD40 molecule Homo sapiens 34-38 7907604-5 1994 Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key role in CD40 ligand gene expression. Cyclosporine 0-13 CD40 molecule Homo sapiens 192-196 7907604-6 1994 Cyclosporin A inhibited IL-4-driven CD40 ligand-dependent IgE isotype switching in PBMC but did not inhibit IgE synthesis induced by CD40 mAb plus IL-4. Cyclosporine 0-13 interleukin 4 Homo sapiens 24-28 7907604-6 1994 Cyclosporin A inhibited IL-4-driven CD40 ligand-dependent IgE isotype switching in PBMC but did not inhibit IgE synthesis induced by CD40 mAb plus IL-4. Cyclosporine 0-13 CD40 molecule Homo sapiens 36-40 7907604-8 1994 These results suggest that patients receiving cyclosporin A may be deficient in CD40 ligand-dependent T cell help. Cyclosporine 46-59 CD40 molecule Homo sapiens 80-84