Pub. Date : 1995 Mar
PMID : 7891318
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism. | Torsemide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | The microsomal reaction was almost completely abolished by the specific CYP2C9 inhibitor sulfaphenazole and was inhibited competitively by the alternative CYP2C9 substrate tolbutamide. | Sulfaphenazole | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | The microsomal reaction was almost completely abolished by the specific CYP2C9 inhibitor sulfaphenazole and was inhibited competitively by the alternative CYP2C9 substrate tolbutamide. | Sulfaphenazole | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | The microsomal reaction was almost completely abolished by the specific CYP2C9 inhibitor sulfaphenazole and was inhibited competitively by the alternative CYP2C9 substrate tolbutamide. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | The microsomal reaction was almost completely abolished by the specific CYP2C9 inhibitor sulfaphenazole and was inhibited competitively by the alternative CYP2C9 substrate tolbutamide. | Tolbutamide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 6 | Torsemide tolyl methylhydroxylase activity in microsomes from 16 human livers correlated significantly (rs = .81-.88) with tolbutamide and phenytoin hydroxylation, both CYP2C9-mediated reactions. | Torsemide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 7 | Complementary DNA-expressed CYP2C9 catalyzed torsemide tolyl methylhydroxylation with an apparent Km (23 microM) similar to that observed for human liver microsomes and the IC50 values for sulfaphenazole inhibition of the reaction were essentially identical for the two enzyme sources. | Torsemide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 8 | Complementary DNA-expressed CYP2C9 catalyzed torsemide tolyl methylhydroxylation with an apparent Km (23 microM) similar to that observed for human liver microsomes and the IC50 values for sulfaphenazole inhibition of the reaction were essentially identical for the two enzyme sources. | Sulfaphenazole | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 9 | Taken together, these data demonstrate that human hepatic torsemide tolyl methylhydroxylation is catalyzed predominantly, if not solely, by CYP2C9. | Torsemide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |