Pub. Date : 1995
PMID : 7850926
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-glycoprotein (Pgp) actively pumps a number of antineoplastic drugs, such as etoposide, out of cancer cells and causes multidrug resistance. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | P-glycoprotein (Pgp) actively pumps a number of antineoplastic drugs, such as etoposide, out of cancer cells and causes multidrug resistance. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | We hypothesized that inhibition of intestinal Pgp might decrease the efflux of etoposide from the blood into the intestinal lumen, thereby, increasing the bioavailability of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 4 | We hypothesized that inhibition of intestinal Pgp might decrease the efflux of etoposide from the blood into the intestinal lumen, thereby, increasing the bioavailability of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 5 | The addition of C219, a monoclonal antibody of Pgp, at 100 ng/ml or of 0.2 M 5"-adenylylimidodiphosphate, a nonhydrolyzable adenosine triphosphate (ATP) analog, increased the absorption of etoposide. | 5"-adenylylimidodiphosphate | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 6 | The addition of C219, a monoclonal antibody of Pgp, at 100 ng/ml or of 0.2 M 5"-adenylylimidodiphosphate, a nonhydrolyzable adenosine triphosphate (ATP) analog, increased the absorption of etoposide. | Adenosine Triphosphate | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 7 | Quinidine, an antiarrythmic agent, has been demonstrated to circumvent multidrug resistance in cell lines, possibly by interfering with Pgp function. | Quinidine | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 8 | The present data confirm that intestinal Pgp mediates the efflux of etoposide and that the use of Pgp-inhibiting agents such as quinidine may increase the bioavailability of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 9 | The present data confirm that intestinal Pgp mediates the efflux of etoposide and that the use of Pgp-inhibiting agents such as quinidine may increase the bioavailability of etoposide. | Quinidine | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 10 | The present data confirm that intestinal Pgp mediates the efflux of etoposide and that the use of Pgp-inhibiting agents such as quinidine may increase the bioavailability of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 11 | The present data confirm that intestinal Pgp mediates the efflux of etoposide and that the use of Pgp-inhibiting agents such as quinidine may increase the bioavailability of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |