Pub. Date : 1995 Jan
PMID : 7843746
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 2 | The purpose of this study was to assess the inhibitory effect of TCV-116, an orally active angiotensin II (Ang II) antagonist, on the pressor action of exogenous Ang II and to determine the compensatory rise in plasma renin activity and Ang II levels. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 3 | The purpose of this study was to assess the inhibitory effect of TCV-116, an orally active angiotensin II (Ang II) antagonist, on the pressor action of exogenous Ang II and to determine the compensatory rise in plasma renin activity and Ang II levels. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 4 | The purpose of this study was to assess the inhibitory effect of TCV-116, an orally active angiotensin II (Ang II) antagonist, on the pressor action of exogenous Ang II and to determine the compensatory rise in plasma renin activity and Ang II levels. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 5 | The purpose of this study was to assess the inhibitory effect of TCV-116, an orally active angiotensin II (Ang II) antagonist, on the pressor action of exogenous Ang II and to determine the compensatory rise in plasma renin activity and Ang II levels. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 6 | Six hours after 4 mg TCV-116, the systolic blood pressure response to a given dose of Ang II was reduced to 40 +/- 4% and 35 +/- 8% of baseline value on days 1 and 8, respectively. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 7 | TCV-116 induced a dose-related increase in plasma renin activity and Ang II levels that was more pronounced on the eighth than on the first day of drug administration. | candesartan cilexetil | renin | Homo sapiens |
| 8 | TCV-116 induced a dose-related increase in plasma renin activity and Ang II levels that was more pronounced on the eighth than on the first day of drug administration. | candesartan cilexetil | angiotensinogen | Homo sapiens |
| 9 | In conclusion, TCV-116 appears to be a well-tolerated, orally active, potent, and long-lasting antagonist of Ang II in men. | candesartan cilexetil | angiotensinogen | Homo sapiens |