Pub. Date : 1995 Feb
PMID : 7835303
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of these cells with forskolin (FSK) caused up-regulation of VDR, whereas treatment with phorbol esters suppressed VDR levels. | Colforsin | vitamin D receptor | Rattus norvegicus |
| 2 | Treatment of these cells with forskolin (FSK) caused up-regulation of VDR, whereas treatment with phorbol esters suppressed VDR levels. | Colforsin | vitamin D receptor | Rattus norvegicus |
| 3 | Treatment of these cells with forskolin (FSK) caused up-regulation of VDR, whereas treatment with phorbol esters suppressed VDR levels. | Phorbol Esters | vitamin D receptor | Rattus norvegicus |
| 4 | PTH or PTH-related protein treatment induced a 2- to 3-fold increase in VDR, which was equivalent to that elicited by FSK in UMR 106-01 cells but less than the FSK-induced increase (approximately 8-fold) in MC3T3-E1 cells. | Colforsin | vitamin D receptor | Rattus norvegicus |
| 5 | In UMR 4-7 cells, a subclone of UMR 106-01 cells that express cAMP resistance due to regulated expression of a mutant form of the type 1 regulatory subunit of the cAMP-dependent protein kinase A (PKA), the up-regulation of VDR abundance due to FSK and PTH treatment was mostly prevented. | Cyclic AMP | vitamin D receptor | Rattus norvegicus |
| 6 | In UMR 4-7 cells, a subclone of UMR 106-01 cells that express cAMP resistance due to regulated expression of a mutant form of the type 1 regulatory subunit of the cAMP-dependent protein kinase A (PKA), the up-regulation of VDR abundance due to FSK and PTH treatment was mostly prevented. | Colforsin | vitamin D receptor | Rattus norvegicus |
| 7 | Thus, exposure of target cells to PTH augments their response to 1,25-dihydroxyvitamin D3 due to up-regulation of VDR abundance. | Calcitriol | vitamin D receptor | Rattus norvegicus |