Protein Name vitamin D receptor
Organism Rattus norvegicus
Gene ID 24873
Gene Symbol

Vdr

UniProt P13053 (VDR_RAT)
Relationships Total Number of functionally related compound(s) : 239
Total Number of Articles : 371
Description

vitamin D receptor

Gene Summary

Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Colocalizes with caveola. Used to study vitamin D-dependent rickets type 2A. Biomarker of secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • vitamin D3 receptor
  • 1,25-dihydroxyvitamin D3 receptor
  • nuclear receptor subfamily 1 group I member 1
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Properties