Title : HS-142-1 inhibits testosterone production and guanosine-3':5'-cyclic monophosphate accumulation stimulated by atrial natriuretic peptide in isolated mouse Leydig cells.

Pub. Date : 1993 Jul

PMID : 7690721






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Incubation of the Leydig cells with 10(-8) M ANP for 3 h resulted in a 16-fold stimulation of testosterone production over basal. Testosterone natriuretic peptide type A Mus musculus
2 Addition of HS-142-1 in a concentration range of 0.1 to 5 micrograms/ml resulted in a dose-dependent inhibition of ANP-induced testosterone production, a nearly complete inhibition being achieved with 5 micrograms/ml antagonist. Testosterone natriuretic peptide type A Mus musculus
3 HS-142-1 was also able to inhibit the ANP-stimulated cyclic guanosine monophosphate (GMP) formation in the cells, in a dose-dependent manner. Cyclic GMP natriuretic peptide type A Mus musculus
4 HS-142-1 was also able to inhibit the ANP-stimulated cyclic guanosine monophosphate (GMP) formation in the cells, in a dose-dependent manner. Guanosine Monophosphate natriuretic peptide type A Mus musculus