Title : Downregulation of male-specific cytochrome P450s 2C11 and 3A2 in bile duct-ligated male rats: importance to reduced hepatic content of cytochrome P450 in cholestasis.

Pub. Date : 1995 Aug

PMID : 7635428






2 Functional Relationships(s)
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1 A possible explanation for downregulation of CYP 2C11 and 3A2 was provided by the observation that serum estradiol concentrations were threefold greater in BDL male rats, while serum testosterone was reduced; estradiol is known to downregulate CYPs 2C11 and 3A2. Testosterone cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 A possible explanation for downregulation of CYP 2C11 and 3A2 was provided by the observation that serum estradiol concentrations were threefold greater in BDL male rats, while serum testosterone was reduced; estradiol is known to downregulate CYPs 2C11 and 3A2. Estradiol cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus