Pub. Date : 1995 Apr
PMID : 7618490
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Changes in dopamine D2 and GluR-1 glutamate receptor mRNAs in the rat brain after treatment with phencyclidine. | Phencyclidine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 2 | In situ hybridization of slide-mounted brain sections from rats subjected to acute and chronic phencyclidine treatment was carried out using synthetic oligonucleotides complementary to dopamine D2-receptor and non-N-methyl-D-aspartate (NMDA) glutamate-receptor-subunit (GluR-1) mRNAs. | Phencyclidine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 3 | However, chronic administration of phencyclidine (10 mg/kg/day, 14 days) significantly decreased the dopamine D2-receptor mRNA level in the caudate-putamen (by 27%, P < 0.01) and significantly increased the GluR-1 mRNA level in the prefrontal cortex (by 29%, P < 0.001). | Phencyclidine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |