Title : Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line.

Pub. Date : 1995 Sep 15

PMID : 7545174






2 Functional Relationships(s)
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1 IP-10 and MIP-1 alpha treatment also evoked significant increases in intracellular cAMP levels. Cyclic AMP C-X-C motif chemokine ligand 10 Homo sapiens
2 Our findings suggest that both MIP-1 alpha and IP-10 mediate their suppressive effects in MO7e cells by stimulating increases in cellular cAMP levels and activating protein kinase A, a mechanism we believe to be unique to these chemokines and not one applied to all growth suppressive members of the chemokine superfamily (for example, interleukin 8 and platelet factor 4). Cyclic AMP C-X-C motif chemokine ligand 10 Homo sapiens