Pub. Date : 1995 Sep 15
PMID : 7545168
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although the receptor for growth hormone (GH) does not contain intrinsic tyrosine kinase activity, GH has recently been shown to promote the association of its receptor with JAK2 tyrosine kinase, to activate JAK2, and to promote the tyrosyl phosphorylation of both GH receptor (GHR) and JAK2. | cyclo(tyrosyl-tyrosyl) | Janus kinase 2 | Rattus norvegicus |
| 2 | In this work, we examined whether tyrosines 333 and/or 338 in GHR are phosphorylated by JAK2 in response to GH. | Tyrosine | Janus kinase 2 | Rattus norvegicus |
| 3 | Consistent with Tyr333 and/or Tyr338 serving as substrates of JAK2, these substitutions resulted in a loss of tyrosyl phosphorylation of truncated receptor in an in vitro kinase assay using substantially purified GH.GHR.JAK2 complexes. | cyclo(tyrosyl-tyrosyl) | Janus kinase 2 | Rattus norvegicus |