Title : The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites.

Pub. Date : 1994 Nov

PMID : 7532082






4 Functional Relationships(s)
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1 Thus, spermine is an inhibitor of the induction of iNOS. Spermine nitric oxide synthase 2, inducible Mus musculus
2 We have, therefore, tested the effects of spermine dialdehyde or malon dialdehyde on the induction of iNOS. N,N'-bis(3-propionaldehyde)-1,4-diaminobutane nitric oxide synthase 2, inducible Mus musculus
3 We have, therefore, tested the effects of spermine dialdehyde or malon dialdehyde on the induction of iNOS. Malondialdehyde nitric oxide synthase 2, inducible Mus musculus
4 The inhibitory effect of polyamines on iNOS induction appears to be fairly specific to iNOS, for spermine does not inhibit LPS-induced production of prostaglandin F2 alpha or tumour necrosis factor. Polyamines nitric oxide synthase 2, inducible Mus musculus