Title : Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: possible mediation via protein kinase C.

Pub. Date : 1995 Feb 6

PMID : 7531975






4 Functional Relationships(s)
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1 Culturing both cell types in high glucose concentration led to significant increases in nitrite production and the mRNA encoding iNOS upon stimulation with LPS plus interferon-gamma, as compared with normal glucose concentration. Glucose nitric oxide synthase 2, inducible Mus musculus
2 High glucose also modestly enhanced LPS/IFN-gamma-induced stimulation of the iNOS promoter in transient transfection experiments in mesangial cells. Glucose nitric oxide synthase 2, inducible Mus musculus
3 Protein kinase C activation led to enhanced mRNA expression of iNOS, and inhibitors of protein kinase C blocked nitrite accumulation in mesangial cells. Nitrites nitric oxide synthase 2, inducible Mus musculus
4 These findings suggest that high glucose in combination with stimulation by LPS plus IFN-gamma enhances iNOS expression, and protein kinase C activation may be playing a role in this enhancement. Glucose nitric oxide synthase 2, inducible Mus musculus