PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7531975-2 1995 Culturing both cell types in high glucose concentration led to significant increases in nitrite production and the mRNA encoding iNOS upon stimulation with LPS plus interferon-gamma, as compared with normal glucose concentration. Glucose 34-41 nitric oxide synthase 2, inducible Mus musculus 129-133 7531975-2 1995 Culturing both cell types in high glucose concentration led to significant increases in nitrite production and the mRNA encoding iNOS upon stimulation with LPS plus interferon-gamma, as compared with normal glucose concentration. Glucose 34-41 interferon gamma Mus musculus 165-181 7531975-3 1995 High glucose also modestly enhanced LPS/IFN-gamma-induced stimulation of the iNOS promoter in transient transfection experiments in mesangial cells. Glucose 5-12 interferon gamma Mus musculus 40-49 7531975-3 1995 High glucose also modestly enhanced LPS/IFN-gamma-induced stimulation of the iNOS promoter in transient transfection experiments in mesangial cells. Glucose 5-12 nitric oxide synthase 2, inducible Mus musculus 77-81 7531975-4 1995 Protein kinase C activation led to enhanced mRNA expression of iNOS, and inhibitors of protein kinase C blocked nitrite accumulation in mesangial cells. Nitrites 112-119 nitric oxide synthase 2, inducible Mus musculus 63-67 7531975-5 1995 These findings suggest that high glucose in combination with stimulation by LPS plus IFN-gamma enhances iNOS expression, and protein kinase C activation may be playing a role in this enhancement. Glucose 33-40 nitric oxide synthase 2, inducible Mus musculus 104-108