Pub. Date : 1995 Jan
PMID : 7530927
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We sought to determine whether expression of the inducible, calcium-independent isoform of nitric oxide synthase (iNOS) contributes to the tissue damage produced by focal cerebral ischemia. | Calcium | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | Twenty-four hours later rats received intraperitoneal injections of the iNOS inhibitor aminoguanidine (100 mg/kg twice per day; n = 10) or of aminoguanidine + L-arginine (300 mg/kg four times per day; n = 7), aminoguanidine + D-arginine (n = 7), arginine alone (n = 6), or vehicle (n = 9). | pimagedine | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | We conclude that aminoguanidine selectively inhibits iNOS activity in the area of infarction and reduces the volume of the infarct produced by middle cerebral artery occlusion. | pimagedine | nitric oxide synthase 2 | Rattus norvegicus |