Title : Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics, clozapine and risperidone.

Pub. Date : 1994 Oct 13

PMID : 7530204






1 Functional Relationships(s)
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1 MDL 100,907 may display antipsychotic properties and the "atypical" antipsychotics, clozapine, risperidone and sertindole, each of which possesses marked affinity at 5-HT2A receptors, abolished the discriminative stimulus effects of DOI (ED50 values of 0.07, 0.03 and 0.33 mg/kg, respectively). Risperidone 5-hydroxytryptamine receptor 2A Homo sapiens