Protein Name 5-hydroxytryptamine receptor 2A
Organism Homo sapiens
Gene ID 3356
Gene Symbol

HTR2A

UniProt P28223 (5HT2A_HUMAN)
Relationships Total Number of functionally related compound(s) : 780
Total Number of Articles : 1588
Description

5-hydroxytryptamine receptor 2A

Gene Summary

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

synonyms
  • 5-hydroxytryptamine receptor 2A
  • 5-HT2 receptor
  • 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
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Properties