Pub. Date : 1994 Nov
PMID : 7526037
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of ethanol on IGF-1 receptor and insulin receptor substrate 1 (IRS-1) tyrosine phosphorylation was determined by immunoprecipitation and Western blotting, as was the phosphatidylinositol 3-kinase content within IRS-1 immunoprecipitates. | Ethanol | insulin-like growth factor 1 receptor | Rattus norvegicus |
| 2 | The inhibition of IGF-1-mediated cell proliferation was accompanied by abrogation of IGF-1 receptor tyrosine autophosphorylation. | Tyrosine | insulin-like growth factor 1 receptor | Rattus norvegicus |
| 3 | CONCLUSIONS: The data indicate that physiologically relevant concentrations of ethanol inhibit the responses of glial cells to IGF-1, including IGF-1 receptor autophosphorylation, IRS-1 and phosphatidylinositol-3 kinase activation, and cell growth. | Ethanol | insulin-like growth factor 1 receptor | Rattus norvegicus |