| Protein Name | insulin-like growth factor 1 receptor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25718 |
| Gene Symbol | Igf1r |
| UniProt | P24062 (IGF1R_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
203
Total Number of Articles : 240 |
Description |
insulin-like growth factor 1 receptor |
| Gene Summary |
Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor receptor activity. Involved in several processes, including cellular response to ketone; cellular response to peptide hormone stimulus; and negative regulation of apoptotic process. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); carcinoma (multiple); diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and toxic encephalopathy. Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Jul 2025] |
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