Title : Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

Pub. Date : 1994 May 20

PMID : 7514175






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We investigated whether dexamethasone and transforming growth factor-beta 1 (TGF-beta 1) suppress iNOS mRNA after its induction by IL-1 beta. Dexamethasone nitric oxide synthase 2 Rattus norvegicus
2 IL-1 beta promoted a dramatic and prolonged induction of RASMC iNOS mRNA that peaked at 48 h. Dexamethasone prevented this induction of iNOS mRNA only when given before the addition of IL-1 beta. Dexamethasone nitric oxide synthase 2 Rattus norvegicus
3 IL-1 beta promoted a dramatic and prolonged induction of RASMC iNOS mRNA that peaked at 48 h. Dexamethasone prevented this induction of iNOS mRNA only when given before the addition of IL-1 beta. Dexamethasone nitric oxide synthase 2 Rattus norvegicus
4 In contrast, TGF-beta 1 inhibited the induction of iNOS mRNA and NO production in RASMC both before and after the addition of IL-1 beta. rasmc nitric oxide synthase 2 Rattus norvegicus