Pub. Date : 1994 Feb
PMID : 7509342
16 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | Nitrogen Dioxide | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | punky blue | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | nicotine 1-N-oxide | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | Cyclic AMP | nitric oxide synthase 2 | Rattus norvegicus |
| 5 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | 8-Bromo Cyclic Adenosine Monophosphate | nitric oxide synthase 2 | Rattus norvegicus |
| 6 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | 8-Bromo Cyclic Adenosine Monophosphate | nitric oxide synthase 2 | Rattus norvegicus |
| 7 | By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). | nicotine 1-N-oxide | nitric oxide synthase 2 | Rattus norvegicus |
| 8 | 8-bromo-cAMP stimulated NOx production and increased steady-state levels of iNOS mRNA in rat VSMC in a time- and dose-dependent manner. | 8-Bromo Cyclic Adenosine Monophosphate | nitric oxide synthase 2 | Rattus norvegicus |
| 9 | Dexamethasone inhibited the stimulated NOx production, as well as the induction of iNOS mRNA by cAMP. | Dexamethasone | nitric oxide synthase 2 | Rattus norvegicus |
| 10 | Dexamethasone inhibited the stimulated NOx production, as well as the induction of iNOS mRNA by cAMP. | Cyclic AMP | nitric oxide synthase 2 | Rattus norvegicus |
| 11 | Actinomycin D abolished the cAMP-induced iNOS mRNA, whereas cycloheximide remarkably increased iNOS mRNA levels in the presence and absence of 8-bromo-cAMP (superinduction). | Dactinomycin | nitric oxide synthase 2 | Rattus norvegicus |
| 12 | Actinomycin D abolished the cAMP-induced iNOS mRNA, whereas cycloheximide remarkably increased iNOS mRNA levels in the presence and absence of 8-bromo-cAMP (superinduction). | Cyclic AMP | nitric oxide synthase 2 | Rattus norvegicus |
| 13 | Actinomycin D abolished the cAMP-induced iNOS mRNA, whereas cycloheximide remarkably increased iNOS mRNA levels in the presence and absence of 8-bromo-cAMP (superinduction). | Cycloheximide | nitric oxide synthase 2 | Rattus norvegicus |
| 14 | Actinomycin D, but not dexamethasone, completely abolished the cycloheximide-induced iNOS mRNA. | Dactinomycin | nitric oxide synthase 2 | Rattus norvegicus |
| 15 | Actinomycin D, but not dexamethasone, completely abolished the cycloheximide-induced iNOS mRNA. | Cycloheximide | nitric oxide synthase 2 | Rattus norvegicus |
| 16 | The half-life of cAMP-induced iNOS mRNA was approximately 2 h, whereas no decay in the cycloheximide-induced iNOS mRNA was observed during 12 h. These results demonstrate that iNOS gene is upregulated by cAMP and the superinduction of iNOS mRNA is attributable to increased mRNA stability in rat VSMC. | Cyclic AMP | nitric oxide synthase 2 | Rattus norvegicus |