Pub. Date : 1994 Feb
PMID : 7507517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rat brain glial cells have the capacity to express a calcium-independent form of nitric oxide synthase (iNOS). | Calcium | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | The presence of tyrphostin-25 (10 microM), which is highly specific for tyrosine kinases, also blocked iNOS induction. | tyrphostin 25 | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | Additional characterization showed that genistein blocked iNOS induction in a dose-dependent manner (IC50 of approximately 40 microM), that the continuous presence of genistein was not necessary to observe inhibition, and that preincubation with genistein led to higher levels of inhibition than the simultaneous addition of genistein and inducers. | Genistein | nitric oxide synthase 2 | Rattus norvegicus |