Title : Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats.

Pub. Date : 1995 Dec

PMID : 7489998






2 Functional Relationships(s)
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1 Because endotoxin levels are elevated in cirrhosis, and endotoxin stimulates inducible nitric oxide synthase (iNOS) expression in several cell lines, aortas of carbon tetrachloride-induced cirrhotic rats with ascites were evaluated for iNOS expression. Carbon Tetrachloride nitric oxide synthase 2 Rattus norvegicus
2 Moreover, aminoguanidine (AG), a preferential inhibitor of iNOS, did not affect phenylephrine contraction of rings with or without endothelium from cirrhotic rats but reversed the blunted response in endotoxin-treated rats. pimagedine nitric oxide synthase 2 Rattus norvegicus