Title : Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.

Pub. Date : 1995 Oct 19

PMID : 7478576






2 Functional Relationships(s)
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Protein Name
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1 In murine fibroblasts activation of the Shc/Grb-2 pathway by the ErbB-2 kinase involves tyrosine phosphorylation of Shc products and the formation of Shc/ErbB-2, Shc/Grb-2 and Grb-2/ErbB-2 complexes. Tyrosine growth factor receptor bound protein 2 Mus musculus
2 Tyr 1139 of ErbB-2 bound to the Grb-2 SH2 domain in vitro as well as in intact cells. Tyrosine growth factor receptor bound protein 2 Mus musculus