Title : Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: effects of hydrocortisone and indomethacin.

Pub. Date : 1981 Dec

PMID : 6271449






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Concentrations of TIMP were usually higher in the culture media of normal, rheumatoid and osteoarthritic synovia when hydrocortisone was present. Hydrocortisone TIMP metallopeptidase inhibitor 1 Homo sapiens
2 The production of TIMP by normal synovia was depressed by indomethacin. Indomethacin TIMP metallopeptidase inhibitor 1 Homo sapiens
3 The ability of hydrocortisone to suppress production of collagenase and to increase free TIMP concentration, as well as to inhibit synthesis of prostaglandin, may explain in part how the drug exerts its therapeutic effects in patients with rheumatoid arthritis. Hydrocortisone TIMP metallopeptidase inhibitor 1 Homo sapiens