Title : Chlordecone (Kepone) exposure in the neonate selectively alters brain and pituitary endorphin levels in prepuberal and adult rats.

Pub. Date : 1982 Oct

PMID : 6186955






2 Functional Relationships(s)
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1 A single injection of chlordecone (1 mg/pup on day 4 of age) reduced the level of [Met5]-enkephalin at 70 and 120 days of age in male rats but not in females. Chlordecone proenkephalin Rattus norvegicus
2 These results suggest that hypothalamo-pituitary axis may be the primary neural target affected by chlordecone and estrogen-like activity may be related to the chlordecone-elicited decrease in pituitary [Met5]-enkephalin level. Chlordecone proenkephalin Rattus norvegicus