Pub. Date : 1982 Apr
PMID : 6178186
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potentiation of CCl4 lethality by chlordecone. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | Previous studies have dealt with the propensity of chlordecone (CD) to potentiate the hepatotoxicity of CCl4. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | Previous studies have dealt with the propensity of chlordecone (CD) to potentiate the hepatotoxicity of CCl4. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | The objective of the present study was to evaluate the effect of CD on CCl4 lethality and several parameters associated with cytochrome P-450 activity. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | CD decrease the LD50 of CCl4 from 2.8 ml/kg to 0.042 ml/kg, representing a 67-fold increase in toxicity, as assessed by lethality. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 6 | These results remain consistent with the proposal that bioactivation is the mechanisms underlying enhanced CCl4 toxicity, but suggest that specific effects of CD upon CCl4 metabolism may be the pivotal mechanism underlying potentiation. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |