Title : Altered erythrocyte pyrimidine activity in vitamin B12 or folate deficiency.

Pub. Date : 1979 May

PMID : 465362






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Altered erythrocyte pyrimidine activity in vitamin B12 or folate deficiency. pyrimidine NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
2 In vitamin B12 or folate deficiency an impressive array of evidence now exists to implicate altered folate metabolism for the observed alterations in purine and pyrimidine metabolism (Das & Herbert, 1976). purine NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
3 In vitamin B12 or folate deficiency an impressive array of evidence now exists to implicate altered folate metabolism for the observed alterations in purine and pyrimidine metabolism (Das & Herbert, 1976). pyrimidine NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
4 In this context the reduced serum uridine plus uracil levels in patients with vitamin B12 deficiency (Parry & Blackmore, 1976) and the haematological response of these patients to orotic acid therapy (Rundles & Brewer, 1958) are not readily explicable. Uridine NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens
5 Since the conversion of orotic acid to uridine monophosphate depends on the integrity of the coupled activities of orotidylic pyrophosphorylase and decarboxylase, this study has quantitated this capacity in peripheral blood erythrocytes in patients with vitamin B12 or folate deficiency. Orotic Acid NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens