Pub. Date : 1985 Oct
PMID : 4060169
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neonatal exposure to toluene: effects on the development of liver microsomal cytochrome P-450 and serum hormone levels in the rat. | Toluene | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 2 | Exposure to 80 ppm toluene decreased the liver microsomal AHH activity and the rate of 7 alpha- and 6 beta-hydroxylation of androstenedione in 8-day-old-pups. | Toluene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | On the other hand, neonatal exposure to 500 or 1000 ppm toluene resulted in a significant increase in AHH and 7-ethoxyresorufin O-deethylase activities and in the formation of 16-oxygenated metabolites of androstenedione in 8-day-old animals. | Toluene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | Exposure to toluene increased the cytochrome P-450 content at all 3 dose levels in male but not in female pups. | Toluene | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 5 | In 56-day-old male rats, however, neonatal exposure to 80 ppm toluene resulted in a decreased rate of 6 beta-hydroxylation of androstenedione and a reduced AHH activity. | Toluene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 6 | In conclusion, exposure to toluene during the first week of life caused significant changes in various liver microsomal cytochrome P-450 dependent enzyme activities in 8-day-old pups, whereas the long-term effects on liver metabolism of the adult animal were small. | Toluene | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |