Pub. Date : 2022 Apr
PMID : 35571453
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway. | Berberine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | BBR-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of c-jun-NH2-kinase (JNK) and the JNK inhibitor (SP600125) significantly suppressed BBR-induced apoptosis, N-acetyl cysteine (NAC), a ROS scavenger, was sufficient to both suppress apoptosis signal-regulating kinase 1 (ASK1) and JNK activation and disrupt apoptotic induction. | Berberine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | BBR-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of c-jun-NH2-kinase (JNK) and the JNK inhibitor (SP600125) significantly suppressed BBR-induced apoptosis, N-acetyl cysteine (NAC), a ROS scavenger, was sufficient to both suppress apoptosis signal-regulating kinase 1 (ASK1) and JNK activation and disrupt apoptotic induction. | Berberine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | BBR-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of c-jun-NH2-kinase (JNK) and the JNK inhibitor (SP600125) significantly suppressed BBR-induced apoptosis, N-acetyl cysteine (NAC), a ROS scavenger, was sufficient to both suppress apoptosis signal-regulating kinase 1 (ASK1) and JNK activation and disrupt apoptotic induction. | pyrazolanthrone | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 6 | BBR-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of c-jun-NH2-kinase (JNK) and the JNK inhibitor (SP600125) significantly suppressed BBR-induced apoptosis, N-acetyl cysteine (NAC), a ROS scavenger, was sufficient to both suppress apoptosis signal-regulating kinase 1 (ASK1) and JNK activation and disrupt apoptotic induction. | pyrazolanthrone | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 7 | BBR-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of c-jun-NH2-kinase (JNK) and the JNK inhibitor (SP600125) significantly suppressed BBR-induced apoptosis, N-acetyl cysteine (NAC), a ROS scavenger, was sufficient to both suppress apoptosis signal-regulating kinase 1 (ASK1) and JNK activation and disrupt apoptotic induction. | Berberine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 8 | BBR-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of c-jun-NH2-kinase (JNK) and the JNK inhibitor (SP600125) significantly suppressed BBR-induced apoptosis, N-acetyl cysteine (NAC), a ROS scavenger, was sufficient to both suppress apoptosis signal-regulating kinase 1 (ASK1) and JNK activation and disrupt apoptotic induction. | Berberine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 9 | Conclusions: The results suggest that BBR induces apoptosis of NSCLC cells via ROS-mediated ASK1/JNK activation and the mitochondrial pathway. | Berberine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 10 | Conclusions: The results suggest that BBR induces apoptosis of NSCLC cells via ROS-mediated ASK1/JNK activation and the mitochondrial pathway. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |