Title : Hox transcript antisense RNA knockdown inhibits osteosarcoma progression by regulating the phosphoinositide 3-kinase/AKT pathway through the microRNA miR-6888-3p/spleen tyrosine kinase axis.

Pub. Date : 2022 Apr

PMID : 35435107






3 Functional Relationships(s)
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1 Luciferase assays, RNA immunoprecipitation (RIP), and RNA pull-down assays were used to detect the relationship between miR-6888-3p and HOTAIR or SYK. mir-6888-3p spleen associated tyrosine kinase Homo sapiens
2 Mechanistically, these results suggest that the HOTAIR sponge, miR-6888-3p, regulates SYK expression. mir-6888-3p spleen associated tyrosine kinase Homo sapiens
3 To summarize, HOTAIR regulates SYK by acting on miR-6888-3p, thereby promoting the proliferation and migration of OS cells. mir-6888-3p spleen associated tyrosine kinase Homo sapiens