Pub. Date : 2022 Jun 12
PMID : 35245628
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Matrix metalloproteinase 14 (MMP14) was validated as the target gene of miR-150-5p, which was overexpressed in Ang II-induced rat heart, rat primary CMs and primary CFs. | mir-150-5p | matrix metallopeptidase 14 | Rattus norvegicus |
| 2 | Matrix metalloproteinase 14 (MMP14) was validated as the target gene of miR-150-5p, which was overexpressed in Ang II-induced rat heart, rat primary CMs and primary CFs. | mir-150-5p | matrix metallopeptidase 14 | Rattus norvegicus |
| 3 | Notably, overexpression of MMP14 induced cardiac remodeling, and reversed the protective role of miR-150-5p in downregulating Ang II-induced upregulation of hypertrophy and fibrosis markers in vitro. | mir-150-5p | matrix metallopeptidase 14 | Rattus norvegicus |
| 4 | CONCLUSION: Collectively, LSZ protects Ang II-induced cardiac dysfunction and remodeling via upregulation of miR-150-5p to target MMP14. | mir-150-5p | matrix metallopeptidase 14 | Rattus norvegicus |